Hydrogen chloride-ethyl acetate → HCID 68661666, compound

HRID 1260847Notes

Reaction equation

HRID 1260847 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([C:17]([NH2:19])=[O:18])[C:5](=[NH:16])[N:6]([CH2:8][C:9]2[CH:14]=[CH:13][CH:12]=[C:11]([Cl:15])[CH:10]=2)[CH:7]=1.Cl.C(OCC)(=O)C>C(OCC)(=O)C>[ClH:1].[Cl:1][C:2]1[CH:3]=[C:4]([C:17]([NH2:19])=[O:18])[C:5](=[NH:16])[N:6]([CH2:8][C:9]2[CH:14]=[CH:13][CH:12]=[C:11]([Cl:15])[CH:10]=2)[CH:7]=1

Participants

4

Reactant 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 250250485-Chloro-1-[(3-chlorophenyl)methyl]-1,2-dihydro-2-imino-3-pyridinecarboxamide

Product 1

HCID 68661666HCID 68661666, compoundYield 151.4%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

5-Chloro-1-(3-chlorobenzyl)-2-imino-1,2-dihydropyridine-3-carboxamide (0.1 g) obtained in Example 19 was dissolved in ethyl acetate (2 ml), and 4N hydrochloric acid-ethyl acetate solution (0.5 ml) was added. The precipitated crystals were collected by filtration to give the title compound (85 mg).

Workup

  1. filtrationThe precipitated crystals were collected by filtration

Sources & evidence

ORD record
ord-f2a01032d6ef46848dd0abf34f1dbc22
Source dataset
uspto-grants-2013_06
Patent number
US08470859B2

Reaction notes

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