2-Cyano-2-(3,4-dichloro-5(2H)-oxo-2-furyl)acetamide → 5-Chloro-2-imino-1-(3,4,5-trifluorobenzyl)-1,2-dihydropyridine-3-carboxamide hydrochloride

HRID 1260873Notes

Reaction equation

HRID 1260873 reaction equation
[C:1]([CH:3]([CH:7]1[C:11]([Cl:12])=[C:10](Cl)C(=O)O1)[C:4]([NH2:6])=[O:5])#[N:2].[F:15][C:16]1[CH:17]=[C:18]([CH2:24][NH2:25])[CH:19]=[C:20]([F:23])[C:21]=1[F:22]>>[ClH:12].[Cl:12][C:11]1[CH:7]=[C:3]([C:4]([NH2:6])=[O:5])[C:1](=[NH:2])[N:25]([CH2:24][C:18]2[CH:19]=[C:20]([F:23])[C:21]([F:22])=[C:16]([F:15])[CH:17]=2)[CH:10]=1

Participants

3

Reactant 2

HCID 5417922-Cyano-2-(3,4-dichloro-5(2H)-oxo-2-furyl)acetamideHCID 27770483,4,5-Trifluorobenzylamine

Product 1

HCID 686619655-Chloro-2-imino-1-(3,4,5-trifluorobenzyl)-1,2-dihydropyridine-3-carboxamide hydrochloride

Procedure

According to the method of Example 160, 2-cyano-2-(3,4-dichloro-5-oxo-2,5-dihydrofuran-2-yl)acetamide was reacted with 1-(3,4,5-trifluorophenyl)methanamine to give the title compound.

Sources & evidence

ORD record
ord-74006f09446f484d82e7e5acb4cb7017
Source dataset
uspto-grants-2013_06
Patent number
US08470859B2

Reaction notes

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