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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1260873Generated: October 27, 2026

2-Cyano-2-(3,4-dichloro-5(2H)-oxo-2-furyl)acetamide → 5-Chloro-2-imino-1-(3,4,5-trifluorobenzyl)-1,2-dihydropyridine-3-carboxamide hydrochloride

https://huagongshe.com/reaction/1260873

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-Cyano-2-(3,4-dichloro-5(2H)-oxo-2-furyl)acetamideHCID 541792—
Reactant3,4,5-TrifluorobenzylamineHCID 2777048—
Product5-Chloro-2-imino-1-(3,4,5-trifluorobenzyl)-1,2-dihydropyridine-3-carboxamide hydrochlorideHCID 68661965—

Reaction Steps

According to the method of Example 160, 2-cyano-2-(3,4-dichloro-5-oxo-2,5-dihydrofuran-2-yl)acetamide was reacted with 1-(3,4,5-trifluorophenyl)methanamine to give the title compound.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08470859B2
Source datasetuspto-grants-2013_06
ORD IDord-74006f09446f484d82e7e5acb4cb7017
Source noteuspto-grants-2013_06