HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl Acetate → 5-Chloro-1-(3-fluoro-5-methylbenzyl)-2-imino-1,2-dihydropyridine-3-carboxamide hydrobromide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl Acetate | HCID 8857 | — |
| Reactant | 3-Fluoro-5-methylbenzyl bromide | HCID 2778451 | — |
| Reactant | 2-Amino-5-chloronicotinamide | HCID 66876883 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 5-Chloro-1-(3-fluoro-5-methylbenzyl)-2-imino-1,2-dihydropyridine-3-carboxamide hydrobromide | HCID 68661622 | 42.4% |
Reaction Steps
A solution of 2-amino-5-chloronicotinamide (150 mg) and 1-(bromomethyl)-3-fluoro-5-methylbenzene (270 mg) in DMF (3 ml) was stirred at 100° C. for 24 hr. After cooling to room temperature, ethyl acetate was added, and the precipitated crystals were filtered and recrystallized to give the title compound (139 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08470859B2 |
| Source dataset | uspto-grants-2013_06 |
| ORD ID | ord-eee8f1bdd6fe409ba3a510730a761f4d |
| Source note | uspto-grants-2013_06 |