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HRID1260880

反应详情

EQUATION

反应方程式

HRID 1260880 的结构方程式

REACTANTS

反应物

3
结构：CCOC(C)=O
HCID8857

Ethyl acetate

C4H8O2

结构：Cc1cc(F)cc(CBr)c1
HCID2778451

3-Fluoro-5-methylbenzyl bromide

C8H8BrF

结构：NC(=O)c1cc(Cl)cnc1N
HCID66876883

2-Amino-5-chloro-3-pyridinecarboxamide

C6H6ClN3O

PRODUCTS

生成物

1
结构：Br.Cc1cc(F)cc(Cn2cc(Cl)cc(C(N)=O)c2=N)c1
HCID68661622

未命名化合物

收率 42.4%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CN(C)C=O
溶剂HCID6228

N,N-Dimethylformamide

C3H7NO

PROCEDURE

实验过程

A solution of 2-amino-5-chloronicotinamide (150 mg) and 1-(bromomethyl)-3-fluoro-5-methylbenzene (270 mg) in DMF (3 ml) was stirred at 100° C. for 24 hr. After cooling to room temperature, ethyl acetate was added, and the precipitated crystals were filtered and recrystallized to give the title compound (139 mg).

WORKUP

后处理

  1. filtrationthe precipitated crystals were filtered
  2. customrecrystallized