3-Fluoro-4-methylbenzyl bromide → 5-Chloro-1-(3-fluoro-4-methylbenzyl)-2-imino-1,2-dihydropyridine-3-carboxamide hydrobromide

HRID 1260883Notes

Reaction equation

HRID 1260883 reaction equation
[NH2:1][C:2]1[N:10]=[CH:9][C:8]([Cl:11])=[CH:7][C:3]=1[C:4]([NH2:6])=[O:5].[Br:12][CH2:13][C:14]1[CH:19]=[CH:18][C:17]([CH3:20])=[C:16]([F:21])[CH:15]=1>>[BrH:12].[Cl:11][C:8]1[CH:7]=[C:3]([C:4]([NH2:6])=[O:5])[C:2](=[NH:1])[N:10]([CH2:13][C:14]2[CH:19]=[CH:18][C:17]([CH3:20])=[C:16]([F:21])[CH:15]=2)[CH:9]=1

Participants

3

Reactant 2

HCID 27746033-Fluoro-4-methylbenzyl bromideHCID 668768832-Amino-5-chloronicotinamide

Product 1

HCID 686614925-Chloro-1-(3-fluoro-4-methylbenzyl)-2-imino-1,2-dihydropyridine-3-carboxamide hydrobromide

Procedure

According to the method of Example 172, 2-amino-5-chloronicotinamide was reacted with 4-(bromomethyl)-2-fluoro-1-methylbenzene to give the title compound.

Sources & evidence

ORD record
ord-39ac05bee61940be9e2f64a107623f58
Source dataset
uspto-grants-2013_06
Patent number
US08470859B2

Reaction notes

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