(3-Morpholinophenyl)methylamine → 5-Chloro-2-imino-1-(3-morpholin-4-ylbenzyl)-1,2-dihydropyridine-3-carboxamide hydrochloride

HRID 1260888Notes

Reaction equation

HRID 1260888 reaction equation
[NH2:1][C:2]1[N:10]=[CH:9][C:8]([Cl:11])=[CH:7][C:3]=1[C:4]([NH2:6])=[O:5].[N:12]1([C:18]2[CH:19]=[C:20]([CH2:24]N)[CH:21]=[CH:22][CH:23]=2)[CH2:17][CH2:16][O:15][CH2:14][CH2:13]1>>[ClH:11].[Cl:11][C:8]1[CH:7]=[C:3]([C:4]([NH2:6])=[O:5])[C:2](=[NH:1])[N:10]([CH2:24][C:20]2[CH:21]=[CH:22][CH:23]=[C:18]([N:12]3[CH2:17][CH2:16][O:15][CH2:14][CH2:13]3)[CH:19]=2)[CH:9]=1

Participants

3

Reactant 2

HCID 2795550(3-Morpholinophenyl)methylamineHCID 668768832-Amino-5-chloronicotinamide

Product 1

HCID 686623925-Chloro-2-imino-1-(3-morpholin-4-ylbenzyl)-1,2-dihydropyridine-3-carboxamide hydrochloride

Procedure

According to the method of Example 179, 2-amino-5-chloronicotinamide was reacted with 1-(3-morpholin-4-ylphenyl)methanamine to give the title compound.

Sources & evidence

ORD record
ord-d773e3a66e84488c8c664269e8112eca
Source dataset
uspto-grants-2013_06
Patent number
US08470859B2

Reaction notes

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