反应详情

(Step 1) To a solution of 3-cyano-5-fluorobenzoic acid (1.0 g) in methanol (20 ml) was added TMS diazomethane (2M diethyl ether solution, 5 ml) at 0° C., and the mixture was stirred for 1 hr. The reaction solution was quenched with water and diluted with ethyl acetate. The organic layer was washed with aqueous sodium hydrogen carbonate solution and then with saturated brine, and dried over anhydrous magnesium sulfate. The solvent was evaporated under reduced pressure to give methyl 3-cyano-5-fluorobenzoate (0.58 g).

1. customThe reaction solution was quenched with water
2. additiondiluted with ethyl acetate
3. washThe organic layer was washed with aqueous sodium hydrogen carbonate solution
4. dry with materialwith saturated brine, and dried over anhydrous magnesium sulfate
5. customThe solvent was evaporated under reduced pressure