2-(Bromomethyl)-5-chlorobenzonitrile → HCID 68662509, compound

HRID 1260901Notes

Reaction equation

HRID 1260901 reaction equation
[NH2:1][C:2]1[N:10]=[CH:9][C:8]([Cl:11])=[CH:7][C:3]=1[C:4]([NH2:6])=[O:5].Br[CH2:13][C:14]1[CH:21]=[CH:20][C:19]([Cl:22])=[CH:18][C:15]=1[C:16]#[N:17]>CN(C)C=O>[ClH:11].[Cl:11][C:8]1[CH:7]=[C:3]([C:4]([NH2:6])=[O:5])[C:2](=[NH:1])[N:10]([CH2:13][C:14]2[CH:21]=[CH:20][C:19]([Cl:22])=[CH:18][C:15]=2[C:16]#[N:17])[CH:9]=1

Participants

4

Reactant 2

HCID 126680522-(Bromomethyl)-5-chlorobenzonitrileHCID 668768832-Amino-5-chloronicotinamide

Product 1

HCID 68662509HCID 68662509, compoundYield 1.8%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Conditions

Temperature
100 °C

Procedure

To a solution of 2-amino-5-chloronicotinamide (0.16 g) in N,N-dimethylformamide (3 ml) was added 2-(bromomethyl)-5-chlorobenzonitrile (0.32 g), and the mixture was stirred at 100° C. for 14 hr. The reaction mixture was quenched with saturated aqueous sodium hydrogen carbonate solution and extracted with ethyl acetate. The extract was washed with saturated brine and dried over anhydrous magnesium sulfate. The solvent was evaporated under reduced pressure, and the obtained residue was purified by silica gel chromatography (ethyl acetate:hexane=3:2-4:1). 2N Hydrochloric acid-methanol solution (1 ml) was added to the obtained yellow oil at room temperature, and the obtained precipitate was recrystallized from methanol-ethyl acetate to give the title compound (3 mg).

Workup

  1. customThe reaction mixture was quenched with saturated aqueous sodium hydrogen carbonate solution
  2. extractionextracted with ethyl acetate
  3. washThe extract was washed with saturated brine
  4. dry with materialdried over anhydrous magnesium sulfate
  5. customThe solvent was evaporated under reduced pressure
  6. customthe obtained residue was purified by silica gel chromatography (ethyl acetate:hexane=3:2-4:1)
  7. addition2N Hydrochloric acid-methanol solution (1 ml) was added to the obtained yellow oil at room temperature
  8. customthe obtained precipitate was recrystallized from methanol-ethyl acetate

Sources & evidence

ORD record
ord-675aab9ae4bd40c69e955e0f7cf1e7f6
Source dataset
uspto-grants-2013_06
Patent number
US08470859B2

Reaction notes

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