HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hexane → tert-butyl (3S,4R)-3-amino-4-(3,4-dichlorophenyl)pyrrolidine-1-carboxylate p-toluenesulfonate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hexane | HCID 8058 | — |
| Reactant | p-Toluenesulfonic acid monohydrate | HCID 521998 | — |
| Reactant | tert-butyl (3S,4R)-3-amino-4-(3,4-dichlorophenyl)pyrrolidine-1-carboxylate | HCID 58356102 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | tert-butyl (3S,4R)-3-amino-4-(3,4-dichlorophenyl)pyrrolidine-1-carboxylate p-toluenesulfonate | HCID 86631350 | 88.7% |
Reaction Steps
To a solution of the compound (0.92 g) obtained in step 5 in ethyl acetate (8 mL) was added p-toluenesulfonic acid monohydrate (0.53 g), and then hexane (1.5 mL) was added. The precipitate was collected by filtration to give tert-butyl (3S,4R)-3-amino-4-(3,4-dichlorophenyl)pyrrolidine-1-carboxylate p-toluenesulfonate (1.24 g, 77%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08470816B2 |
| Source dataset | uspto-grants-2013_06 |
| ORD ID | ord-114adbfe6b7b4c63bc70e43d24693b8f |
| Source note | uspto-grants-2013_06 |