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HRID1260942

反应详情

EQUATION

反应方程式

HRID 1260942 的结构方程式

REACTANTS

反应物

3
结构：CCCCCC
HCID8058

n-Hexane

C6H14

结构：Cc1ccc(S(=O)(=O)O)cc1.O
HCID521998

4-Methylbenzenesulfonic acid hydrate

C7H10O4S

结构：CC(C)(C)OC(=O)N1C[C@@H](N)[C@H](c2ccc(Cl)c(Cl)c2)C1
HCID58356102

未命名化合物

PRODUCTS

生成物

1
结构：CC(C)(C)OC(=O)N1C[C@@H](N)[C@H](c2ccc(Cl)c(Cl)c2)C1.Cc1ccc(S(=O)(=O)O)cc1
HCID86631350

未命名化合物

收率 88.7%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CCOC(C)=O
溶剂HCID8857

Ethyl acetate

C4H8O2

PROCEDURE

实验过程

To a solution of the compound (0.92 g) obtained in step 5 in ethyl acetate (8 mL) was added p-toluenesulfonic acid monohydrate (0.53 g), and then hexane (1.5 mL) was added. The precipitate was collected by filtration to give tert-butyl (3S,4R)-3-amino-4-(3,4-dichlorophenyl)pyrrolidine-1-carboxylate p-toluenesulfonate (1.24 g, 77%).

WORKUP

后处理

  1. filtrationThe precipitate was collected by filtration