Cyclopropylboronic acid → HCID 68932049, compound

HRID 1260947Notes

Reaction equation

[C:1]([N:4]1[CH2:9][CH2:8][CH:7]([C:10]([N:12]2[CH2:17][CH2:16][C@@H:15]([N:18]([CH3:29])[C:19](=[O:28])[C:20]3[CH:25]=[CH:24][C:23]([O:26][CH3:27])=[CH:22][CH:21]=3)[C@H:14]([C:30]3[CH:35]=[CH:34][C:33](Br)=[CH:32][CH:31]=3)[CH2:13]2)=[O:11])[CH2:6][CH2:5]1)(=[O:3])[CH3:2].[CH:37]1(B(O)O)[CH2:39][CH2:38]1>>[C:1]([N:4]1[CH2:9][CH2:8][CH:7]([C:10]([N:12]2[CH2:17][CH2:16][C@@H:15]([N:18]([CH3:29])[C:19](=[O:28])[C:20]3[CH:25]=[CH:24][C:23]([O:26][CH3:27])=[CH:22][CH:21]=3)[C@H:14]([C:30]3[CH:35]=[CH:34][C:33]([CH:37]4[CH2:39][CH2:38]4)=[CH:32][CH:31]=3)[CH2:13]2)=[O:11])[CH2:6][CH2:5]1)(=[O:3])[CH3:2]

Participants

Reactant 2

HCID 2760897Cyclopropylboronic acid

HCID 68935939HCID 68935939, compound

Product 1

HCID 68932049HCID 68932049, compound

Procedure

Using the compound obtained in Example 239 and cyclopropylboronic acid (0.066 g), and by the reaction and purification in the same manner as in Example 242, the title compound was obtained.

Workup

customby the reaction and purification in the same manner as in Example 242

Sources & evidence

ORD record: ord-90c36bd074f34084b3c7ee0eeef2bf51
Source dataset: uspto-grants-2013_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08470816B2

Reaction notes

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