HRID1260950

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID522268

4-Fluoro-3-(trifluoromethyl)benzoic acid

C8H4F4O2

结构：CN[C@@H]1CCN(C(=O)C2CCN(C(C)=O)CC2)C[C@H]1c1ccc(Cl)c(Cl)c1

HCID57741761

未命名化合物

PRODUCTS

生成物

结构：CC(=O)N1CCC(C(=O)N2CC[C@@H](N(C)C(=O)c3ccc(F)c(C(F)(F)F)c3)[C@H](c3ccc(Cl)c(Cl)c3)C2)CC1

HCID86631353

未命名化合物

PROCEDURE

实验过程

Using the compound obtained in Example 78 and 4-fluoro-3-trifluoromethylbenzoic acid, and by the reaction and purification in the same manner as in Example 3, the title compound was obtained.

WORKUP

后处理

customby the reaction and purification in the same manner as in Example 3

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-cb09d069df8e4f23b3a719946771a2a2
来源数据集: uspto-grants-2013_06
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08470816B2
来源说明: uspto-grants-2013_06

反应 SMILES

[C:1]([N:4]1[CH2:9][CH2:8][CH:7]([C:10]([N:12]2[CH2:17][CH2:16][C@@H:15]([NH:18][CH3:19])[C@H:14]([C:20]3[CH:25]=[CH:24][C:23]([Cl:26])=[C:22]([Cl:27])[CH:21]=3)[CH2:13]2)=[O:11])[CH2:6][CH2:5]1)(=[O:3])[CH3:2].[F:28][C:29]1[CH:37]=[CH:36][C:32]([C:33]([OH:35])=O)=[CH:31][C:30]=1[C:38]([F:41])([F:40])[F:39]>>[C:1]([N:4]1[CH2:5][CH2:6][CH:7]([C:10]([N:12]2[CH2:17][CH2:16][C@@H:15]([N:18]([CH3:19])[C:33](=[O:35])[C:32]3[CH:36]=[CH:37][C:29]([F:28])=[C:30]([C:38]([F:41])([F:40])[F:39])[CH:31]=3)[C@H:14]([C:20]3[CH:25]=[CH:24][C:23]([Cl:26])=[C:22]([Cl:27])[CH:21]=3)[CH2:13]2)=[O:11])[CH2:8][CH2:9]1)(=[O:3])[CH3:2]