4-Fluoro-3-(trifluoromethyl)benzoic acid → N-[(3R,4R)-1-[(1-acetylpiperidin-4-yl)carbonyl]-3-(3,4-dichlorophenyl)piperidin-4-yl]-4-fluoro-N-methyl-3-(trifluoromethyl)benzamide

Participants

Role	Name	HCID	Charge
Reactant	4-Fluoro-3-(trifluoromethyl)benzoic acid	HCID 522268	—
Reactant	(3R,4R)-1-[(1-acetylpiperidin-4-yl)carbonyl]-3-(3,4-dichlorophenyl)-N-methylpiperidin-4-amine	HCID 57741761	—
Product	N-[(3R,4R)-1-[(1-acetylpiperidin-4-yl)carbonyl]-3-(3,4-dichlorophenyl)piperidin-4-yl]-4-fluoro-N-methyl-3-(trifluoromethyl)benzamide	HCID 86631353	—

Reaction Steps

Using the compound obtained in Example 78 and 4-fluoro-3-trifluoromethylbenzoic acid, and by the reaction and purification in the same manner as in Example 3, the title compound was obtained.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08470816B2
Source dataset	uspto-grants-2013_06
ORD ID	ord-cb09d069df8e4f23b3a719946771a2a2
Source note	uspto-grants-2013_06