HRID1260954

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CN[C@@H]1CCN(C(=O)C2CCN(C(C)=O)CC2)C[C@H]1c1ccc(Cl)c(Cl)c1

HCID57741761

未命名化合物

HCID68935618

未命名化合物

PRODUCTS

生成物

结构：COc1cc2c(cc1C(=O)N(C)[C@@H]1CCN(C(=O)C3CCN(C(C)=O)CC3)C[C@H]1c1ccc(Cl)c(Cl)c1)N(C)C(=O)CC2

HCID68933811

未命名化合物

PROCEDURE

实验过程

Using the compound obtained in step 1 and the compound obtained in Example 78, and by the reaction and purification in the same manner as in Example 3, the title compound was obtained.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-a863c599924d4c0b9757272343909be9
来源数据集: uspto-grants-2013_06
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08470816B2
来源说明: uspto-grants-2013_06

反应 SMILES

[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][C:12]=1[C:13]([OH:15])=O)[N:9]([CH3:16])[C:8](=[O:17])[CH2:7][CH2:6]2.[C:18]([N:21]1[CH2:26][CH2:25][CH:24]([C:27]([N:29]2[CH2:34][CH2:33][C@@H:32]([NH:35][CH3:36])[C@H:31]([C:37]3[CH:42]=[CH:41][C:40]([Cl:43])=[C:39]([Cl:44])[CH:38]=3)[CH2:30]2)=[O:28])[CH2:23][CH2:22]1)(=[O:20])[CH3:19]>>[C:18]([N:21]1[CH2:22][CH2:23][CH:24]([C:27]([N:29]2[CH2:34][CH2:33][C@@H:32]([N:35]([CH3:36])[C:13]([C:12]3[CH:11]=[C:10]4[C:5]([CH2:6][CH2:7][C:8](=[O:17])[N:9]4[CH3:16])=[CH:4][C:3]=3[O:2][CH3:1])=[O:15])[C@H:31]([C:37]3[CH:42]=[CH:41][C:40]([Cl:43])=[C:39]([Cl:44])[CH:38]=3)[CH2:30]2)=[O:28])[CH2:25][CH2:26]1)(=[O:20])[CH3:19]