(3R*,4R*)-1-[(1-acetylpiperidin-4-yl)carbonyl]-3-(3,4-dichlorophenyl)-N-methylpiperidin-4-amine → N-[(3R,4R)-1-[(1-acetylpiperidin-4-yl)carbonyl]-3-(3,4-dichlorophenyl)piperidin-4-yl]-6-methoxy-N,1-dimethyl-2-oxo-1,2,3,4-tetrahydroquinoline-7-carboxamide

HRID 1260954Notes

Reaction equation

HRID 1260954 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][C:12]=1[C:13]([OH:15])=O)[N:9]([CH3:16])[C:8](=[O:17])[CH2:7][CH2:6]2.[C:18]([N:21]1[CH2:26][CH2:25][CH:24]([C:27]([N:29]2[CH2:34][CH2:33][C@@H:32]([NH:35][CH3:36])[C@H:31]([C:37]3[CH:42]=[CH:41][C:40]([Cl:43])=[C:39]([Cl:44])[CH:38]=3)[CH2:30]2)=[O:28])[CH2:23][CH2:22]1)(=[O:20])[CH3:19]>>[C:18]([N:21]1[CH2:22][CH2:23][CH:24]([C:27]([N:29]2[CH2:34][CH2:33][C@@H:32]([N:35]([CH3:36])[C:13]([C:12]3[CH:11]=[C:10]4[C:5]([CH2:6][CH2:7][C:8](=[O:17])[N:9]4[CH3:16])=[CH:4][C:3]=3[O:2][CH3:1])=[O:15])[C@H:31]([C:37]3[CH:42]=[CH:41][C:40]([Cl:43])=[C:39]([Cl:44])[CH:38]=3)[CH2:30]2)=[O:28])[CH2:25][CH2:26]1)(=[O:20])[CH3:19]

Participants

3

Reactant 2

HCID 57741761(3R*,4R*)-1-[(1-acetylpiperidin-4-yl)carbonyl]-3-(3,4-dichlorophenyl)-N-methylpiperidin-4-amineHCID 689356186-Methoxy-1-methyl-2-oxo-1,2,3,4-tetrahydroquinoline-7-carboxylic acid

Product 1

HCID 68933811N-[(3R,4R)-1-[(1-acetylpiperidin-4-yl)carbonyl]-3-(3,4-dichlorophenyl)piperidin-4-yl]-6-methoxy-N,1-dimethyl-2-oxo-1,2,3,4-tetrahydroquinoline-7-carboxamide

Procedure

Using the compound obtained in step 1 and the compound obtained in Example 78, and by the reaction and purification in the same manner as in Example 3, the title compound was obtained.

Sources & evidence

ORD record
ord-a863c599924d4c0b9757272343909be9
Source dataset
uspto-grants-2013_06
Patent number
US08470816B2

Reaction notes

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