HCID 86631415, compound → HCID 68933780, compound

HRID 1260984Notes

Reaction equation

HRID 1260984 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([C@H:9]2[C@H:14]([N:15]([CH3:30])[C:16]([C:18]3[CH:23]=[CH:22][C:21]([N:24]4[CH2:29][CH2:28][O:27][CH2:26][CH2:25]4)=[CH:20][CH:19]=3)=[O:17])[CH2:13][CH2:12][N:11]([C:31]([C@H:33]3[CH2:38][CH2:37][O:36][CH2:35][C@H:34]3[NH:39]C(=O)OC(C)(C)C)=[O:32])[CH2:10]2)[CH:5]=[CH:6][C:7]=1[Cl:8]>Cl.CC(O)C>[ClH:1].[NH2:39][C@H:34]1[C@@H:33]([C:31]([N:11]2[CH2:12][CH2:13][C@@H:14]([N:15]([CH3:30])[C:16](=[O:17])[C:18]3[CH:19]=[CH:20][C:21]([N:24]4[CH2:29][CH2:28][O:27][CH2:26][CH2:25]4)=[CH:22][CH:23]=3)[C@H:9]([C:4]3[CH:5]=[CH:6][C:7]([Cl:8])=[C:2]([Cl:1])[CH:3]=3)[CH2:10]2)=[O:32])[CH2:38][CH2:37][O:36][CH2:35]1

Participants

3

Reactant 1

HCID 86631415HCID 86631415, compound

Product 1

HCID 68933780HCID 68933780, compoundYield 249.5%

Reagents, catalysts & solvents 1

HCID 21912024Isopropanol hydrochlorideSolvent

Procedure

A solution of tert-butyl [(3S,4S)-4-{[(3R,4R)-3-(3,4-dichlorophenyl)-4-{methyl[(4-morpholin-4-ylphenyl)carbonyl]amino}piperidin-1-yl]carbonyl}tetrahydro-2H-pyran-3-yl]carbamate (200 mg) obtained in Example 627 in 2N hydrogen chloride/2-propanol (5 mL) was stirred at 55° C. for 2 hr. The reaction mixture was concentrated under reduced pressure to give the title compound (226 mg, 100%) as a white powder.

Workup

  1. concentrationThe reaction mixture was concentrated under reduced pressure

Sources & evidence

ORD record
ord-2ffd539990794a0584df341391bc41d3
Source dataset
uspto-grants-2013_06
Patent number
US08470816B2

Reaction notes

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