HRID1260990

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID774012

1-(methylsulfonyl)piperidine-4-carboxylic acid

C7H13NO4S

结构：CN(C(=O)c1ccc(C2CC2)cc1)[C@@H]1CCNC[C@H]1c1ccc(Cl)c(Cl)c1

HCID68935262

未命名化合物

PRODUCTS

生成物

结构：CN(C(=O)c1ccc(C2CC2)cc1)[C@@H]1CCN(C(=O)C2CCN(S(C)(=O)=O)CC2)C[C@H]1c1ccc(Cl)c(Cl)c1

HCID68934030

未命名化合物

PROCEDURE

实验过程

Using the compound obtained in step 1 and 1-(methylsulfonyl)piperidine-4-carboxylic acid, and by the reaction and purification in the same manner as in Example 97, the title compound was obtained.

WORKUP

后处理

customby the reaction and purification in the same manner as in Example 97

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-698cc4a4cdfb4855b4f107f9351902b1
来源数据集: uspto-grants-2013_06
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08470816B2
来源说明: uspto-grants-2013_06

反应 SMILES

[CH:1]1([C:4]2[CH:27]=[CH:26][C:7]([C:8]([N:10]([C@@H:12]3[CH2:17][CH2:16][NH:15][CH2:14][C@H:13]3[C:18]3[CH:23]=[CH:22][C:21]([Cl:24])=[C:20]([Cl:25])[CH:19]=3)[CH3:11])=[O:9])=[CH:6][CH:5]=2)[CH2:3][CH2:2]1.[CH3:28][S:29]([N:32]1[CH2:37][CH2:36][CH:35]([C:38](O)=[O:39])[CH2:34][CH2:33]1)(=[O:31])=[O:30]>>[CH:1]1([C:4]2[CH:27]=[CH:26][C:7]([C:8]([N:10]([C@@H:12]3[CH2:17][CH2:16][N:15]([C:38]([CH:35]4[CH2:36][CH2:37][N:32]([S:29]([CH3:28])(=[O:31])=[O:30])[CH2:33][CH2:34]4)=[O:39])[CH2:14][C@H:13]3[C:18]3[CH:23]=[CH:22][C:21]([Cl:24])=[C:20]([Cl:25])[CH:19]=3)[CH3:11])=[O:9])=[CH:6][CH:5]=2)[CH2:3][CH2:2]1