1-Methanesulfonylpiperidine-4-carboxylic acid → 4-cyclopropyl-N-[(3R,4R)-3-(3,4-dichlorophenyl)-1-{[1-(methylsulfonyl)piperidin-4-yl]carbonyl}piperidin-4-yl]-N-methylbenzamide

HRID 1260990Notes

Reaction equation

HRID 1260990 reaction equation
[CH:1]1([C:4]2[CH:27]=[CH:26][C:7]([C:8]([N:10]([C@@H:12]3[CH2:17][CH2:16][NH:15][CH2:14][C@H:13]3[C:18]3[CH:23]=[CH:22][C:21]([Cl:24])=[C:20]([Cl:25])[CH:19]=3)[CH3:11])=[O:9])=[CH:6][CH:5]=2)[CH2:3][CH2:2]1.[CH3:28][S:29]([N:32]1[CH2:37][CH2:36][CH:35]([C:38](O)=[O:39])[CH2:34][CH2:33]1)(=[O:31])=[O:30]>>[CH:1]1([C:4]2[CH:27]=[CH:26][C:7]([C:8]([N:10]([C@@H:12]3[CH2:17][CH2:16][N:15]([C:38]([CH:35]4[CH2:36][CH2:37][N:32]([S:29]([CH3:28])(=[O:31])=[O:30])[CH2:33][CH2:34]4)=[O:39])[CH2:14][C@H:13]3[C:18]3[CH:23]=[CH:22][C:21]([Cl:24])=[C:20]([Cl:25])[CH:19]=3)[CH3:11])=[O:9])=[CH:6][CH:5]=2)[CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 7740121-Methanesulfonylpiperidine-4-carboxylic acidHCID 689352624-cyclopropyl-N-[(3R,4R)-3-(3,4-dichlorophenyl)piperidin-4-yl]-N-methylbenzamide

Product 1

HCID 689340304-cyclopropyl-N-[(3R,4R)-3-(3,4-dichlorophenyl)-1-{[1-(methylsulfonyl)piperidin-4-yl]carbonyl}piperidin-4-yl]-N-methylbenzamide

Procedure

Using the compound obtained in step 1 and 1-(methylsulfonyl)piperidine-4-carboxylic acid, and by the reaction and purification in the same manner as in Example 97, the title compound was obtained.

Workup

  1. customby the reaction and purification in the same manner as in Example 97

Sources & evidence

ORD record
ord-698cc4a4cdfb4855b4f107f9351902b1
Source dataset
uspto-grants-2013_06
Patent number
US08470816B2

Reaction notes

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