1-Methanesulfonylpiperidine-4-carboxylic acid → 4-cyclopropyl-N-[(3R,4R)-3-(3,4-dichlorophenyl)-1-{[1-(methylsulfonyl)piperidin-4-yl]carbonyl}piperidin-4-yl]-N-methylbenzamide

Participants

Role	Name	HCID	Charge
Reactant	1-Methanesulfonylpiperidine-4-carboxylic acid	HCID 774012	—
Reactant	4-cyclopropyl-N-[(3R,4R)-3-(3,4-dichlorophenyl)piperidin-4-yl]-N-methylbenzamide	HCID 68935262	—
Product	4-cyclopropyl-N-[(3R,4R)-3-(3,4-dichlorophenyl)-1-{[1-(methylsulfonyl)piperidin-4-yl]carbonyl}piperidin-4-yl]-N-methylbenzamide	HCID 68934030	—

Reaction Steps

Using the compound obtained in step 1 and 1-(methylsulfonyl)piperidine-4-carboxylic acid, and by the reaction and purification in the same manner as in Example 97, the title compound was obtained.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08470816B2
Source dataset	uspto-grants-2013_06
ORD ID	ord-698cc4a4cdfb4855b4f107f9351902b1
Source note	uspto-grants-2013_06