1-(Cyclopropylcarbonyl)piperidine-4-carboxylic acid → N-[(3R,4R)-1-{[1-(cyclopropylcarbonyl)piperidin-4-yl]carbonyl}-3-(3,4-dichlorophenyl)piperidin-4-yl]-N-methyl-4-(trifluoromethyl)benzamide

HRID 1260993Notes

Reaction equation

HRID 1260993 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([C@H:9]2[C@H:14]([N:15]([CH3:28])[C:16](=[O:27])[C:17]3[CH:22]=[CH:21][C:20]([C:23]([F:26])([F:25])[F:24])=[CH:19][CH:18]=3)[CH2:13][CH2:12][NH:11][CH2:10]2)[CH:5]=[CH:6][C:7]=1[Cl:8].[CH:29]1([C:32]([N:34]2[CH2:39][CH2:38][CH:37]([C:40](O)=[O:41])[CH2:36][CH2:35]2)=[O:33])[CH2:31][CH2:30]1>>[CH:29]1([C:32]([N:34]2[CH2:35][CH2:36][CH:37]([C:40]([N:11]3[CH2:12][CH2:13][C@@H:14]([N:15]([CH3:28])[C:16](=[O:27])[C:17]4[CH:22]=[CH:21][C:20]([C:23]([F:26])([F:24])[F:25])=[CH:19][CH:18]=4)[C@H:9]([C:4]4[CH:5]=[CH:6][C:7]([Cl:8])=[C:2]([Cl:1])[CH:3]=4)[CH2:10]3)=[O:41])[CH2:38][CH2:39]2)=[O:33])[CH2:30][CH2:31]1

Participants

3

Reactant 2

HCID 89029151-(Cyclopropylcarbonyl)piperidine-4-carboxylic acidHCID 68934058N-[(3R,4R)-3-(3,4-dichlorophenyl)piperidin-4-yl]-N-methyl-4-(trifluoromethyl)benzamide

Product 1

HCID 68930394N-[(3R,4R)-1-{[1-(cyclopropylcarbonyl)piperidin-4-yl]carbonyl}-3-(3,4-dichlorophenyl)piperidin-4-yl]-N-methyl-4-(trifluoromethyl)benzamide

Procedure

Using the compound obtained in step 1 and 1-(cyclopropylcarbonyl)piperidine-4-carboxylic acid, and by the reaction and purification in the same manner as in Example 97, the title compound was obtained.

Workup

  1. customby the reaction and purification in the same manner as in Example 97

Sources & evidence

ORD record
ord-124ee376ccb349b3b91589f9b7d27db1
Source dataset
uspto-grants-2013_06
Patent number
US08470816B2

Reaction notes

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