1-(Cyclopropylcarbonyl)piperidine-4-carboxylic acid → N-[(3R,4R)-1-{[1-(cyclopropylcarbonyl)piperidin-4-yl]carbonyl}-3-(3,4-dichlorophenyl)piperidin-4-yl]-N-methyl-4-(trifluoromethyl)benzamide

Participants

Role	Name	HCID	Charge
Reactant	1-(Cyclopropylcarbonyl)piperidine-4-carboxylic acid	HCID 8902915	—
Reactant	N-[(3R,4R)-3-(3,4-dichlorophenyl)piperidin-4-yl]-N-methyl-4-(trifluoromethyl)benzamide	HCID 68934058	—
Product	N-[(3R,4R)-1-{[1-(cyclopropylcarbonyl)piperidin-4-yl]carbonyl}-3-(3,4-dichlorophenyl)piperidin-4-yl]-N-methyl-4-(trifluoromethyl)benzamide	HCID 68930394	—

Reaction Steps

Using the compound obtained in step 1 and 1-(cyclopropylcarbonyl)piperidine-4-carboxylic acid, and by the reaction and purification in the same manner as in Example 97, the title compound was obtained.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08470816B2
Source dataset	uspto-grants-2013_06
ORD ID	ord-124ee376ccb349b3b91589f9b7d27db1
Source note	uspto-grants-2013_06