1-(Cyclopropylcarbonyl)piperidine-4-carboxylic acid → 4-bromo-N-[(3R,4R)-1-{[1-(cyclopropylcarbonyl)piperidin-4-yl]carbonyl}-3-(3,4-dichlorophenyl)piperidin-4-yl]-N-methylbenzamide

HRID 1260996Notes

Reaction equation

HRID 1260996 reaction equation
[Br:1][C:2]1[CH:25]=[CH:24][C:5]([C:6]([N:8]([C@@H:10]2[CH2:15][CH2:14][NH:13][CH2:12][C@H:11]2[C:16]2[CH:21]=[CH:20][C:19]([Cl:22])=[C:18]([Cl:23])[CH:17]=2)[CH3:9])=[O:7])=[CH:4][CH:3]=1.[CH:26]1([C:29]([N:31]2[CH2:36][CH2:35][CH:34]([C:37](O)=[O:38])[CH2:33][CH2:32]2)=[O:30])[CH2:28][CH2:27]1>>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([C:6]([N:8]([C@@H:10]2[CH2:15][CH2:14][N:13]([C:37]([CH:34]3[CH2:33][CH2:32][N:31]([C:29]([CH:26]4[CH2:28][CH2:27]4)=[O:30])[CH2:36][CH2:35]3)=[O:38])[CH2:12][C@H:11]2[C:16]2[CH:21]=[CH:20][C:19]([Cl:22])=[C:18]([Cl:23])[CH:17]=2)[CH3:9])=[O:7])=[CH:24][CH:25]=1

Participants

3

Reactant 2

HCID 89029151-(Cyclopropylcarbonyl)piperidine-4-carboxylic acidHCID 689301054-bromo-N-[(3R,4R)-3-(3,4-dichlorophenyl)piperidin-4-yl]-N-methylbenzamide

Product 1

HCID 688726684-bromo-N-[(3R,4R)-1-{[1-(cyclopropylcarbonyl)piperidin-4-yl]carbonyl}-3-(3,4-dichlorophenyl)piperidin-4-yl]-N-methylbenzamide

Procedure

Using the compound obtained in Example 633, step 3 and 1-(cyclopropylcarbonyl)piperidine-4-carboxylic acid, and by the reaction and purification in the same manner as in Example 97, the title compound was obtained.

Workup

  1. customby the reaction and purification in the same manner as in Example 97

Sources & evidence

ORD record
ord-d8ef719a9da54748b36d737c5c326f56
Source dataset
uspto-grants-2013_06
Patent number
US08470816B2

Reaction notes

Loading…