Triacetoxyperiodinane → HCID 58086109、化合物

HRID 1261080ノート

反応式

HRID 1261080 の反応式
[Cl:1][C:2]1[CH:27]=[CH:26][C:5]([CH2:6][O:7][C:8]2[CH:13]=[CH:12][C:11]([CH:14]([C:16]3[C:24]4[C:19](=[N:20][CH:21]=[CH:22][CH:23]=4)[NH:18][CH:17]=3)[OH:15])=[CH:10][C:9]=2[F:25])=[CH:4][CH:3]=1.CC(OI1(OC(C)=O)(OC(C)=O)OC(=O)C2C=CC=CC1=2)=O>O1CCCC1>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:6][O:7][C:8]2[CH:13]=[CH:12][C:11]([C:14]([C:16]3[C:24]4[C:19](=[N:20][CH:21]=[CH:22][CH:23]=4)[NH:18][CH:17]=3)=[O:15])=[CH:10][C:9]=2[F:25])=[CH:26][CH:27]=1

参加物

4

反応物 2

HCID 159087TriacetoxyperiodinaneHCID 58086104[4-(4-chloro-benzyloxy)-3-fluoro-phenyl]-(1H-pyrrolo[2,3-b]pyridin-3-yl)-methanol

生成物 1

HCID 58086109HCID 58086109、化合物

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

To [4-(4-chloro-benzyloxy)-3-fluoro-phenyl]-(1H-pyrrolo[2,3-b]pyridin-3-yl)-methanol (P-1895, 17.7 mg, 0.046 mmol) in tetrahydrofuran (10.0 mL) was added Dess-Martin periodinane (23.5 mg, 0.056 mmol). The reaction was stirred at room temperature for 15 minutes. The reaction was concentrated, then purified with silica gel column chromatography eluting with 50% ethyl acetate in hexane to give a white solid (P-1897, 6.4 mg, 36.3%). MS (ESI) [M+H4]+=381.3.

後処理

  1. concentrationThe reaction was concentrated
  2. custompurified with silica gel column chromatography
  3. washeluting with 50% ethyl acetate in hexane

出典と根拠

ORDレコード
ord-b11e39c1269b47a3aa6afc8aba1a5b0d
出典データセット
uspto-grants-2013_06
特許番号
US08470818B2

反応ノート

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