化工社化工社 化学情報印刷レポート · 研究参考用
Hydrochloric Acid → Methyl 3-(chlorocarbonyl)-5-nitrobenzoate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | 1,3-Benzenedicarboxylic acid, 5-nitro-, 1-methyl ester | HCID 74776 | — |
| 溶媒 | Thionyl Chloride | HCID 24386 | — |
| 生成物 | Methyl 3-(chlorocarbonyl)-5-nitrobenzoate | HCID 74774 | — |
反応手順
A suspension of 5-nitro-isophthalic acid mono methyl ester (22.52 g, 100.0 mmol) in thionyl chloride (50 ml) was heated to reflux for 6 hours (until the production of SO2 and HCl-gas ceased). The excess of thionyl chloride was removed under reduced pressure, the residue was dissolved in DCM and the product was precipitated by addition of hexane to give a white solid. Yield: 24.10 g (99%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08470860B2 |
| 出典データセット | uspto-grants-2013_06 |
| ORD ID | ord-0fba3e45dacc44129240e3da748448cb |
| 出典メモ | uspto-grants-2013_06 |