反应详情

A suspension of 5-nitro-isophthalic acid mono methyl ester (22.52 g, 100.0 mmol) in thionyl chloride (50 ml) was heated to reflux for 6 hours (until the production of SO2 and HCl-gas ceased). The excess of thionyl chloride was removed under reduced pressure, the residue was dissolved in DCM and the product was precipitated by addition of hexane to give a white solid. Yield: 24.10 g (99%).

1. temperaturewas heated
2. customThe excess of thionyl chloride was removed under reduced pressure
3. dissolutionthe residue was dissolved in DCM
4. customthe product was precipitated by addition of hexane
5. customto give a white solid