反应详情

To a solution of 39 (2.0 g, 5.98 mmol) in anhydrous CH2Cl2 (30 ml) under an atmosphere of nitrogen, was added oxalyl chloride (2.6 ml, 29.8 mmol). After stirring for 2 hours the solvent was evaporated, anhydrous toluene (10 mL) was added and the resultant mixture was evaporated (procedure of addition of toluene followed by evaporation was performed twice) to afford title compound 40 (2.2 g, 94% yield) as a white solid. The product was used without further purification and characterization and was assumed to be the mono-HCl salt.

1. customwas evaporated
2. additionanhydrous toluene (10 mL) was added
3. customthe resultant mixture was evaporated (
4. additionprocedure of addition of toluene
5. customfollowed by evaporation