Dodecylamine → HCID 59424435, compound

HRID 1261255Notes

Reaction equation

HRID 1261255 reaction equation
[S:1]1[CH:5]=[CH:4][N:3]=[C:2]1[C:6]1[S:14][C:13]2[C:8](=[N:9][CH:10]=C[C:12]=2[O:15][C:16]2[CH:21]=[CH:20][C:19]([NH:22]C(NC(=O)CC3C=CC=CC=3)=S)=[CH:18][C:17]=2[F:35])[CH:7]=1.CCCCCCCCCCCC[NH2:48]>>[F:35][C:17]1[CH:18]=[C:19]([NH2:22])[CH:20]=[CH:21][C:16]=1[O:15][C:12]1[C:13]2[S:14][C:6]([C:2]3[S:1][CH:5]=[CH:4][N:3]=3)=[CH:7][C:8]=2[N:9]=[CH:10][N:48]=1

Participants

3

Reactant 2

HCID 13583DodecylamineHCID 11598848HCID 11598848, compound

Product 1

HCID 59424435HCID 59424435, compoundYield 7%

Procedure

Starting from the nitro compound 150, following the procedure described above for the synthesis of compound 13a (via the intermediate amine 12, scheme 2, example 12), title compound 152a was obtained [via intermediate 3-fluoro-4-(6-(thiazol-2-yl)thieno[3,2-d]pyrimidin-4-yloxy)benzenamine (151)] in 7% yield. Characterization of 152a is provided in the Table 14.

Sources & evidence

ORD record
ord-eab288a2776a44f784776b4aef8e000f
Source dataset
uspto-grants-2013_06
Patent number
US08470850B2

Reaction notes

Loading…