反应详情

To a suspension of 231 (61 mg) in THF (2 mL) was added 2-phenylacetyl isothiocyanate (42 mg, 0.199 mmol). The reaction mixture was stirred for 3 hours, concentrated under reduced pressure and the residue was purified by column chromatography, eluent EtOAc/hexane (35:65), to produce yellow oil. Purification of this material by preparative HPLC (column C-18 Aquasil, gradient: 60% MeOH to 95% MeOH) afforded title compound 232a (25 mg, 26% yield) as a cream solid. Characterization of 232a is provided in the table 22.

1. concentrationconcentrated under reduced pressure
2. customthe residue was purified by column chromatography, eluent EtOAc/hexane (35:65)
3. customto produce yellow oil
4. customPurification of this material by preparative HPLC (column C-18 Aquasil, gradient: 60% MeOH to 95% MeOH)