反应详情

To a solution of 260 (100 mg, 0.36 mmol) in AcOH (4 mL) at 90° C., was added iron powder (102 mg, 2.1 mmol). The reaction mixture was vigorously stirred for 10 min, cooled, filtered through a Celite pad and concentrated. The residue was purified by flash column chromatography, eluent EtOAc/hexane (1:1), to afford title compound 261 (87 mg, 99% yield) as an off-white solid. MS (m/z): 244.1(M+H) (found).

1. temperaturecooled
2. filtrationfiltered through a Celite pad
3. concentrationconcentrated
4. customThe residue was purified by flash column chromatography, eluent EtOAc/hexane (1:1)