Dichloromethane → 2-[7-(2-methoxyethoxy)imidazo[1,2-a]pyridin-3-yl]-N-pyrrolidin-3-ylquinolin-8-amine

HRID 126148Notes

Reaction equation

HRID 126148 reaction equation
[CH3:1][O:2][CH2:3][CH2:4][O:5][c:6]1[cH:7][c:8]2[n:9]([cH:10][cH:11]1)[c:12](-[c:15]1[n:16][c:17]3[c:18]([NH:25][CH:26]4[CH2:27][N:28]([C:31]([O:32][C:33]([CH3:34])([CH3:35])[CH3:36])=[O:37])[CH2:29][CH2:30]4)[cH:19][cH:20][cH:21][c:22]3[cH:23][cH:24]1)[cH:13][n:14]2.[Cl:45][CH2:46][Cl:47].[OH:38][C:39]([C:40]([F:41])([F:42])[F:43])=[O:44]>>[CH3:1][O:2][CH2:3][CH2:4][O:5][c:6]1[cH:7][c:8]2[n:9]([cH:10][cH:11]1)[c:12](-[c:15]1[n:16][c:17]3[c:18]([NH:25][CH:26]4[CH2:27][NH:28][CH2:29][CH2:30]4)[cH:19][cH:20][cH:21][c:22]3[cH:23][cH:24]1)[cH:13][n:14]2

Participants

4

Reactant 3

HCID 6344DichloromethaneHCID 6422Trifluoroacetic acidHCID 66782045Tert-butyl 3-[[2-[7-(2-methoxyethoxy)imidazo[1,2-a]pyridin-3-yl]quinolin-8-yl]amino]pyrrolidine-1-carboxylate

Product 1

HCID 667814622-[7-(2-methoxyethoxy)imidazo[1,2-a]pyridin-3-yl]-N-pyrrolidin-3-ylquinolin-8-amine

Sources & evidence

ORD record
ord-96cf9d42da644dd28aced159139d12b9
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Reaction notes

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