反应详情

To methanol (10 mL), thionyl chloride (0.76 mL) was added dropwise at −15 to −10° C., followed by stirring for 30 minutes. To the mixture, (4-bromo-1H-indol-3-yl)acetic acid (Chemical and Pharmaceutical Bulletin, 33(9), 3696-3708 (1985), 1.32 g) was added, followed by stifling at room temperature for 2 hours. To the reaction mixture, an aqueous saturated sodium hydrogen carbonate solution was added, followed by extraction with ethyl acetate. The organic layer was washed in turn with water and saturated saline, dried and then concentrated. The residue was washed with diisopropyl ether/n-hexane (1:2) to obtain the titled compound having the following physical properties (1.26 g).

1. waitby stifling at room temperature for 2 hours
2. extractionfollowed by extraction with ethyl acetate
3. washThe organic layer was washed in turn with water and saturated saline
4. customdried
5. concentrationconcentrated
6. washThe residue was washed with diisopropyl ether/n-hexane (1:2)