1,4-Dibromobutane → HCID 66672175, compound

HRID 1261537Notes

Reaction equation

HRID 1261537 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([NH2:8])=[C:4]([C:9]([F:12])([F:11])[F:10])[CH:3]=1.[H-].[Na+].Br[CH2:16][CH2:17][CH2:18][CH2:19]Br>>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[CH2:19][CH2:18][CH2:17][CH2:16]2)=[C:4]([C:9]([F:10])([F:11])[F:12])[CH:3]=1

Participants

4

Reactant 3

HCID 80561,4-DibromobutaneHCID 24758Sodium hydrideHCID 679604-Bromo-2-(trifluoromethyl)aniline

Product 1

HCID 66672175HCID 66672175, compoundYield 17.3%

Procedure

In a manner similar to that of Example 18a, by reacting 40 g of 4-bromo-2-trifluoromethylphenylamine (0.167 mol) with 16.6 g of sodium hydride (0.42 mol) and 49.7 mL of 1,4-dibromobutane (0.42 mol), 8.5 g of 1-(4-bromo-2-trifluoromethylphenyl)pyrrolidine (yield=17%) are obtained in the form of a yellow oil.

Sources & evidence

ORD record
ord-d359b67ad79b45559a45db96930d78f7
Source dataset
uspto-grants-2013_06
Patent number
US08470871B2

Reaction notes

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