Butylamine → HCID 178449181, compound

HRID 1261552Notes

Reaction equation

HRID 1261552 reaction equation
[CH2:1]([NH2:5])[CH2:2][CH2:3][CH3:4].[CH:6]([N:9]=[C:10]=[N:11][CH:12]([CH3:14])[CH3:13])([CH3:8])[CH3:7]>>[CH2:1]([NH:5][C:10]([NH:11][CH:12]([CH3:14])[CH3:13])=[N:9][CH:6]([CH3:8])[CH3:7])[CH2:2][CH2:3][CH3:4]

Participants

3

Reactant 2

HCID 8007ButylamineHCID 12734Diisopropylcarbodiimide2×

Product 1

HCID 178449181HCID 178449181, compoundYield 96.7%

Procedure

A mixture of 33 g of N-butylamine (0.45 mol) and 19 g of diisopropylcarbodiimide (0.15 mol) is heated at reflux for 3 hours 30 minutes. GC analysis then shows a conversion of more than 99.5% of the diisopropylcarbodiimide. The final mixture, which is colorless, is concentrated at 60° C. under 20 mbar for 2 hours, to give 29 g of a colorless and virtually odorless liquid of low viscosity, which corresponds to the expected guanidine (96.7% yield).

Workup

  1. temperatureis heated
  2. temperatureat reflux for 3 hours 30 minutes
  3. concentrationis concentrated at 60° C. under 20 mbar for 2 hours
  4. customto give 29 g of a colorless and virtually odorless liquid of low viscosity, which

Sources & evidence

ORD record
ord-cd6e0fc779e849f1b0638f5f4d1367ca
Source dataset
uspto-grants-2013_06
Patent number
US08470950B2

Reaction notes

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