N-Methylbutylamine → HCID 58238473, compound

HRID 1261553Notes

Reaction equation

HRID 1261553 reaction equation
[CH2:1]([NH:5][CH3:6])[CH2:2][CH2:3][CH3:4].[CH:7]([N:10]=[C:11]=[N:12][CH:13]([CH3:15])[CH3:14])([CH3:9])[CH3:8]>>[CH2:1]([N:5]([CH3:6])[C:11]([NH:12][CH:13]([CH3:15])[CH3:14])=[N:10][CH:7]([CH3:9])[CH3:8])[CH2:2][CH2:3][CH3:4]

Participants

3

Reactant 2

HCID 8068N-MethylbutylamineHCID 12734Diisopropylcarbodiimide2×

Product 1

HCID 58238473HCID 58238473, compoundYield 100%

Procedure

A mixture of 32.68 g of N-butyl-N-methylamine (0.375 mol) and 23.66 g of diisopropylcarbodiimide (0.1875 mol) is heated at reflux for 3 hours. GC analysis then shows a conversion of more than 99.5% of the diisopropylcarbodiimide. The final mixture, which is colorless, is concentrated at 60° C. under 5 mbar for 2 hours, to give 40 g of a colorless and virtually odorless liquid of low viscosity, which corresponds to the expected guanidine (100% yield).

Workup

  1. temperatureis heated
  2. temperatureat reflux for 3 hours
  3. concentrationis concentrated at 60° C. under 5 mbar for 2 hours
  4. customto give 40 g of a colorless and virtually odorless liquid of low viscosity, which

Sources & evidence

ORD record
ord-57351f66abd34bce8beba820a32873e2
Source dataset
uspto-grants-2013_06
Patent number
US08470950B2

Reaction notes

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