反应详情

To a dichloromethane (50 mL) solution of aluminum chloride (6.80 g), succinic acid monoethyl ester chloride (8.39 g) was added under ice cooling and the mixture was stirred for 30 minutes. To the mixture, 7-bromoindole (5.0 g) was added, followed by stirring at room temperature for 5 hours. To the reaction mixture, ice water and ethyl acetate were added, followed by extraction with ethyl acetate. The organic layer was washed in turn with water and saturated saline, dried over anhydrous sodium sulfate and then concentrated. The residue was washed with diisopropyl ether to obtain the titled compound having the following physical properties (6.04 g).

1. stirringby stirring at room temperature for 5 hours
2. extractionfollowed by extraction with ethyl acetate
3. washThe organic layer was washed in turn with water and saturated saline
4. dry with materialdried over anhydrous sodium sulfate
5. concentrationconcentrated
6. washThe residue was washed with diisopropyl ether