Trifluoroacetic acid → 4-[2-(Trifluoromethyl)phenyl]-1,2,3,6-tetrahydropyridine

HRID 1261657Notes

Reaction equation

HRID 1261657 reaction equation
[F:1][C:2]([F:23])([F:22])[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[C:9]1[CH2:10][CH2:11][N:12](C(OC(C)(C)C)=O)[CH2:13][CH:14]=1.FC(F)(F)C(O)=O>C(Cl)Cl>[F:23][C:2]([F:1])([F:22])[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[C:9]1[CH2:14][CH2:13][NH:12][CH2:11][CH:10]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 22707864HCID 22707864, compound

Product 1

HCID 227078634-[2-(Trifluoromethyl)phenyl]-1,2,3,6-tetrahydropyridine

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of tert-butyl 4-[2-(trifluoromethyl)phenyl]-3,6-dihydropyridine-1(2H)-carboxylate (200 mg, 0.61 mmol) in methylene chloride (5 mL) was added trifluoroacetic acid (2.5 mL). After being stirred at room temperature for 45 min, the solution was concentrated to give an oil. MS calculated for C12H12F3N: (M+H) 228; found 228.1.

Workup

  1. concentrationthe solution was concentrated
  2. customto give an oil

Sources & evidence

ORD record
ord-84edca31b72e4d9a928d8b1cd02587ba
Source dataset
uspto-grants-2013_06
Patent number
US08470827B2

Reaction notes

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