反应详情

A 500 mL round-bottomed flask equipped with a stirrer was charged with 4-[(E)-3-(4-chloro-2-phenylamino-phenyl)-3-oxo-propenyl]-benzoic acid methyl ester (5.5 g, 14.0 mmol) and ethyl acetate (100 mL). The resulting mixture was stirred under a hydrogen atmosphere for 1 h. At this time, the catalyst was removed by filtration and washed with ethyl acetate. The filtrates were concentrated in vacuo to afford 4-[3-(4-chloro-2-phenylamino-phenyl)-3-oxo-propyl]-benzoic acid methyl ester (5.5 g, 99.5%) as a gummy solid. This material was used without further purification.

1. customA 500 mL round-bottomed flask equipped with a stirrer
2. customAt this time, the catalyst was removed by filtration
3. washwashed with ethyl acetate
4. concentrationThe filtrates were concentrated in vacuo