Ethanol → HCID 86661406, compound

HRID 1261822Notes

Reaction equation

HRID 1261822 reaction equation
[C:1]([O:5][C:6]([NH:8][C@H:9]([CH:21](O)[C:22]1[CH:27]=[C:26]([F:28])[C:25]([F:29])=[CH:24][C:23]=1[F:30])[CH2:10][C:11]([O:13][CH2:14][C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)=[O:12])=[O:7])([CH3:4])([CH3:3])[CH3:2].C(O)C>CO>[C:1]([O:5][C:6]([NH:8][C@H:9]([CH2:21][C:22]1[CH:27]=[C:26]([F:28])[C:25]([F:29])=[CH:24][C:23]=1[F:30])[CH2:10][C:11]([O:13][CH2:14][C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)=[O:12])=[O:7])([CH3:4])([CH3:2])[CH3:3]

Participants

4

Reactant 2

HCID 702EthanolHCID 51354787HCID 51354787, compound

Product 1

HCID 86661406HCID 86661406, compoundYield 79.9%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

In accordance with the method described in Example 6, except that 43.94 g (3S)-benzyl 3-(tert-butoxycarbonylamino)-4-hydroxy-4-(2,4,5-trifluorophenyl)butyrate and an equal amount of anhydrous ethanol were used to replace (3S)-3-(tert-butoxycarbonylamino)-4-hydroxy-4-(2,4,5-trifluorophenyl)n-butyl ester and methanol respectively, 33.83 g (R)-benzyl 3-(tert-butoxycarbonylamino)-4-(2,4,5-trifluorophenyl)butyrate (yield: 77%) was obtained using the same method.

Sources & evidence

ORD record
ord-e081714b129d4947a7157ed108af2c2a
Source dataset
uspto-grants-2013_06
Patent number
US08471057B2

Reaction notes

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