Ethanol → HCID 68089168, compound

HRID 1261823Notes

Reaction equation

HRID 1261823 reaction equation
[C:1]([O:5][C:6]([NH:8][C@H:9]([CH:20](O)[C:21]1[CH:26]=[C:25]([F:27])[C:24]([F:28])=[CH:23][C:22]=1[F:29])[CH2:10][C:11]([O:13][CH:14]1[CH2:19][CH2:18][CH2:17][CH2:16][CH2:15]1)=[O:12])=[O:7])([CH3:4])([CH3:3])[CH3:2].C(O)C>CO>[C:1]([O:5][C:6]([NH:8][C@H:9]([CH2:20][C:21]1[CH:26]=[C:25]([F:27])[C:24]([F:28])=[CH:23][C:22]=1[F:29])[CH2:10][C:11]([O:13][CH:14]1[CH2:19][CH2:18][CH2:17][CH2:16][CH2:15]1)=[O:12])=[O:7])([CH3:4])([CH3:2])[CH3:3]

Participants

4

Reactant 2

HCID 702EthanolHCID 51355076HCID 51355076, compound

Product 1

HCID 68089168HCID 68089168, compoundYield 79%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

In accordance with the method described in Example 6, except that 43.14 g (3S)-cyclohexyl 3-(tert-butoxycarbonylamino)-4-hydroxy-4-(2,4,5-trifluorophenyl)butyrate and an equal amount of anhydrous ethanol were used to replace (3S)-3-(tert-butoxycarbonylamino)-4-hydroxy-4-(2,4,5-trifluorophenyl)n-butyl ester and methanol respectively, 32.82 g (R)-cyclohexyl 3-(tert-butoxycarbonylamino)-4-(2,4,5-trifluorophenyl)butyrate (yield: 79%) was obtained using the same method.

Sources & evidence

ORD record
ord-ed20837efb30474897d504fafdcbc829
Source dataset
uspto-grants-2013_06
Patent number
US08471057B2

Reaction notes

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