Hydrochloric Acid → 4,4-Difluoro-6-azaspiro[2.5]octane--hydrogen chloride (1/1)

HRID 1261833Notes

Reaction equation

HRID 1261833 reaction equation
[ClH:1].[F:2][C:3]1([F:18])[CH2:10][N:9](C(OC(C)(C)C)=O)[CH2:8][CH2:7][C:4]21[CH2:6][CH2:5]2>C(O)C>[ClH:1].[F:2][C:3]1([F:18])[CH2:10][NH:9][CH2:8][CH2:7][C:4]21[CH2:6][CH2:5]2

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 67092985HCID 67092985, compound

Product 1

HCID 670930794,4-Difluoro-6-azaspiro[2.5]octane--hydrogen chloride (1/1)Yield 92.1%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Hydrogen chloride (4 M in dioxane, 3.29 ml, 13.2 mmol) was added to a solution of tert-butyl 4,4-difluoro-6-azaspiro[2.5]octane-6-carboxylate (592 mg, 2.39 mmol) in ethanol (0.5 ml). The solvents were evaporated to give a white solid. The solid residue was washed with tert-butylmethylether to afford the title compound (404 mg, 92%).White solid, MS: 148.2 (M+H)+.

Workup

  1. customThe solvents were evaporated
  2. customto give a white solid
  3. washThe solid residue was washed with tert-butylmethylether

Sources & evidence

ORD record
ord-65fef0f0ddec403681d84d39b3c23ed0
Source dataset
uspto-grants-2013_06
Patent number
US08471004B2

Reaction notes

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