反应详情

1.3 g of N-tert.-butyloxycarbonyl-L-glutamic acid 5-methyl ester 1-tert.-butyl ester (1.2., 4.12 mmol) are dissolved in 15 ml of acetonitrile and mixed with 100 mg of N,N-dimethyl-4-aminopyridine (DMAP). A solution of 1.79 g of di-tert.-butyl-bicarbonate (8.2 mmol) in 7 ml of acetonitrile is added under nitrogen atmosphere. After stirring overnight, the solvent is removed under vacuum and the crude product obtained is purified by means of chromatography on silica gel.

1. customthe solvent is removed under vacuum