HCID 66710773, compound → HCID 66711761, compound

HRID 1261985Notes

Reaction equation

HRID 1261985 reaction equation
CS([C:4]1[N:9]=[CH:8][C:7]2=CC=[C:12]([C:13]3[CH:18]=CC=CC=3OC)[N:6]2[N:5]=1)=O.[Cl:21][C:22]1[CH:23]=[C:24]([C:28]2[N:36]3[C:31]([CH:32]=[N:33][C:34](S(C)=O)=[N:35]3)=[CH:30][CH:29]=2)[CH:25]=[CH:26][CH:27]=1>>[Cl:21][C:22]1[CH:23]=[C:24]([C:28]2[N:36]3[C:31]([CH:32]=[N:33][C:34]([N:5]4[C:18]5[CH:13]=[CH:12][N:6]=[CH:7][C:8]=5[N:9]=[CH:4]4)=[N:35]3)=[CH:30][CH:29]=2)[CH:25]=[CH:26][CH:27]=1

Participants

3

Reactant 2

HCID 66710773HCID 66710773, compoundHCID 667107912-Methanesulfinyl-7-(2-methoxy-phenyl)-pyrrolo[2,1-f][1,2,4]triazine

Product 1

HCID 66711761HCID 66711761, compound

Procedure

The compound was made in an analogous fashion to Example 322 replacing 2-Methanesulfinyl-7-(2-methoxy-phenyl)-pyrrolo[2,1-f][1,2,4]triazine with 7-(3-Chloro-phenyl)-2-methanesulfinyl-pyrrolo[2,1-f][1,2,4]triazine to afford 90.14 mg of 1-[7-(3-Chloro-phenyl)-pyrrolo[2,1-f][1,2,4]triazin-2-yl]-1H-imidazo[4,5-c]pyridine as a lyophilized powder. (M+H)=347.6. 1H NMR (400 MHz, DMSO, d6) δ 9.42 (s, 1H), 9.21 (s, 1H), 8.61 (m, 1H), 8.53 (m, 1H), 8.35 (m, 1H), 8.15 (m, 1H), 7.63 (m, 4H), 7.36 (d, 1H, J=4.89 Hz).

Sources & evidence

ORD record
ord-298509c1bcc84a48bb66750609cf9371
Source dataset
uspto-grants-2013_06
Patent number
US08471005B2

Reaction notes

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