HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethanol → [1-(4-Amino-phenyl)-piperidin-3-yl]-(4-methyl-piperazin-1-yl)-methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethanol | HCID 702 | — |
| Reactant | 2-Methoxy-4-(4-methylpiperazin-1-yl)aniline | HCID 20136253 | — |
| Reactant | 1-(3-Methoxy-4-nitrophenyl)-4-methylpiperazine | HCID 56777243 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | [1-(4-Amino-phenyl)-piperidin-3-yl]-(4-methyl-piperazin-1-yl)-methanone | HCID 66711816 | — |
Reaction Steps
[1-(4-Amino-phenyl)-piperidin-3-yl]-(4-methyl-piperazin-1-yl)-methanone was prepared in a similar manner as 2-Methoxy-4-(4-methyl-piperazin-1-yl)-phenylamine of Example 33 after substituting (4-Methyl-piperazin-1-yl)-[1-(4-nitro-phenyl)-piperidin-3-yl]-methanone for 1-(3-Methoxy-4-nitro-phenyl)-4-methyl-piperazine, and using EtOH as the solvent rather than MeOH (75 mg, 99%). LC/MS (E/I+) 303.19 (M+H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08471005B2 |
| Source dataset | uspto-grants-2013_06 |
| ORD ID | ord-eda792184ab041dcb6e6da5d26ad046c |
| Source note | uspto-grants-2013_06 |