Pyrrolidine → 1-(3-Methoxy-4-nitro-phenyl)-4-pyrrolidin-1-yl-piperidine

HRID 1262058Notes

Reaction equation

HRID 1262058 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([N:12]2[CH2:17][CH2:16][CH:15]([N:18]([CH3:20])[CH3:19])[CH2:14][CH2:13]2)[CH:6]=[CH:7][C:8]=1[N+:9]([O-:11])=[O:10].N1CC[CH2:23][CH2:22]1>>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([N:12]2[CH2:17][CH2:16][CH:15]([N:18]3[CH2:19][CH2:23][CH2:22][CH2:20]3)[CH2:14][CH2:13]2)[CH:6]=[CH:7][C:8]=1[N+:9]([O-:11])=[O:10]

Participants

3

Reactant 2

HCID 31268PyrrolidineHCID 574161521-(3-methoxy-4-nitrophenyl)-N,N-dimethylpiperidin-4-amine

Product 1

HCID 574161471-(3-Methoxy-4-nitro-phenyl)-4-pyrrolidin-1-yl-piperidine

Procedure

1-(3-Methoxy-4-nitro-phenyl)-4-pyrrolidin-1-yl-piperidine was prepared in an analogous fashion to [1-(3-Methoxy-4-nitro-phenyl)-piperidine-4-yl]dimethyl-amine of Example 475a replacing Dimethylamine with Pyrrolidine. The crude material was used after workup without further manipulation (350 mg, 96%).

Sources & evidence

ORD record
ord-fe3c31d005f242bda233a757f5cdcaa1
Source dataset
uspto-grants-2013_06
Patent number
US08471005B2

Reaction notes

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