(3-Methoxy-4-nitrophenyl)(4-methylpiperazin-1-yl)methanone → (4-Amino-3-methoxyphenyl)(4-methylpiperazin-1-yl)methanone

HRID 1262063Notes

Reaction equation

HRID 1262063 reaction equation
NC1C=CC(N2CCC[C@H](C(N3CCN(C)CC3)=O)C2)=CC=1OC.[CH3:25][O:26][C:27]1[CH:28]=[C:29]([C:36]([N:38]2[CH2:43][CH2:42][N:41]([CH3:44])[CH2:40][CH2:39]2)=[O:37])[CH:30]=[CH:31][C:32]=1[N+:33]([O-])=O>>[NH2:33][C:32]1[CH:31]=[CH:30][C:29]([C:36]([N:38]2[CH2:39][CH2:40][N:41]([CH3:44])[CH2:42][CH2:43]2)=[O:37])=[CH:28][C:27]=1[O:26][CH3:25]

Participants

3

Reactant 2

HCID 66711301(3-Methoxy-4-nitrophenyl)(4-methylpiperazin-1-yl)methanoneHCID 66711468HCID 66711468, compound

Product 1

HCID 57416164(4-Amino-3-methoxyphenyl)(4-methylpiperazin-1-yl)methanone

Procedure

(4-Amino-3-methoxy-phenyl)-(4-methyl-piperazin-1-yl)-methanone was prepared in an analogous fashion to [(S)-1-(4-Amino-3-methoxy-phenyl)-piperidin-3-yl]-(4-methyl-piperazin-1-yl)-methanone of Example 460c replacing [(S)-1-(3-Methoxy-4-nitro-phenyl)-piperidin-3-yl]-(4-methyl-piperazin-1-yl)-methanone with (3-Methoxy-4-nitro-phenyl)-(4-methyl-piperazin-1-yl)-methanone.

Sources & evidence

ORD record
ord-92b9a4a1453944dea4b8130694a2994b
Source dataset
uspto-grants-2013_06
Patent number
US08471005B2

Reaction notes

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