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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1262063Generated: November 4, 2026

(3-Methoxy-4-nitrophenyl)(4-methylpiperazin-1-yl)methanone → (4-Amino-3-methoxyphenyl)(4-methylpiperazin-1-yl)methanone

https://huagongshe.com/reaction/1262063

Reaction equation

Participants

RoleNameHCIDCharge
Reactant(3-Methoxy-4-nitrophenyl)(4-methylpiperazin-1-yl)methanoneHCID 66711301—
ReactantHCID 66711468HCID 66711468—
Product(4-Amino-3-methoxyphenyl)(4-methylpiperazin-1-yl)methanoneHCID 57416164—

Reaction Steps

(4-Amino-3-methoxy-phenyl)-(4-methyl-piperazin-1-yl)-methanone was prepared in an analogous fashion to [(S)-1-(4-Amino-3-methoxy-phenyl)-piperidin-3-yl]-(4-methyl-piperazin-1-yl)-methanone of Example 460c replacing [(S)-1-(3-Methoxy-4-nitro-phenyl)-piperidin-3-yl]-(4-methyl-piperazin-1-yl)-methanone with (3-Methoxy-4-nitro-phenyl)-(4-methyl-piperazin-1-yl)-methanone.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08471005B2
Source datasetuspto-grants-2013_06
ORD IDord-92b9a4a1453944dea4b8130694a2994b
Source noteuspto-grants-2013_06