4-(4-Methoxy-3-nitrobenzoyl)morpholine → 2-Methoxy-5-(morpholine-4-carbonyl)aniline

HRID 1262066Notes

Reaction equation

HRID 1262066 reaction equation
NC1C=CC(N2CCC[C@H](C(N3CCN(C)CC3)=O)C2)=CC=1OC.[CH3:25][O:26][C:27]1[CH:32]=[CH:31][C:30]([C:33]([N:35]2[CH2:40][CH2:39][O:38][CH2:37][CH2:36]2)=[O:34])=[CH:29][C:28]=1[N+:41]([O-])=O>>[NH2:41][C:28]1[CH:29]=[C:30]([C:33]([N:35]2[CH2:36][CH2:37][O:38][CH2:39][CH2:40]2)=[O:34])[CH:31]=[CH:32][C:27]=1[O:26][CH3:25]

Participants

3

Reactant 2

HCID 7116054-(4-Methoxy-3-nitrobenzoyl)morpholineHCID 66711468HCID 66711468, compound

Product 1

HCID 167704782-Methoxy-5-(morpholine-4-carbonyl)aniline

Procedure

(3-Amino-4-methoxy-phenyl)-morpholin-4-yl-methanone was prepared in an analogous fashion to [(S)-1-(4-Amino-3-methoxy-phenyl)-piperidin-3-yl]-(4-methyl-piperazin-1-yl)-methanone of Example 460c replacing [(S)-1-(3-Methoxy-4-nitro-phenyl)-piperidin-3-yl]-(4-methyl-piperazin-1-yl)-methanone with (4-Methoxy-3-nitro-phenyl)-morpholin-4-yl-methanone. LC/MS (E/I+) 237.05 (M+H).

Sources & evidence

ORD record
ord-264318ba339a4437a0f42b315450a843
Source dataset
uspto-grants-2013_06
Patent number
US08471005B2

Reaction notes

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