2-Methoxy-5-(morpholine-4-carbonyl)aniline → 2-Methoxy-5-morpholin-4-ylmethyl-phenylamine

HRID 1262067Notes

Reaction equation

HRID 1262067 reaction equation
COC1C=CC(CN2CCN(C)CC2)=CC=1N.[NH2:18][C:19]1[CH:20]=[C:21]([C:27]([N:29]2[CH2:34][CH2:33][O:32][CH2:31][CH2:30]2)=O)[CH:22]=[CH:23][C:24]=1[O:25][CH3:26]>>[CH3:26][O:25][C:24]1[CH:23]=[CH:22][C:21]([CH2:27][N:29]2[CH2:34][CH2:33][O:32][CH2:31][CH2:30]2)=[CH:20][C:19]=1[NH2:18]

Participants

3

Reactant 2

HCID 167704782-Methoxy-5-(morpholine-4-carbonyl)anilineHCID 293012072-Methoxy-5-((4-methylpiperazin-1-yl)methyl)aniline

Product 1

HCID 295595242-Methoxy-5-morpholin-4-ylmethyl-phenylamine

Procedure

2-Methoxy-5-morpholin-4-ylmethyl-phenylamine was prepared in an analogous fashion to 2-Methoxy-5-(4-methyl-piperazin-1-ylmethyl)-phenylamine of Example 495a replacing (3-Amino-4-methoxy-phenyl)-(4-methyl-piperazin-1-yl)-methanone with (3-Amino-4-methoxy-phenyl)-morpholin-4-yl-methanone (1.31 g, 73%). LC/MS (E/I+) 223.05 (M+H).

Sources & evidence

ORD record
ord-7ed3001f4a6b4a51968b7fecc31333e3
Source dataset
uspto-grants-2013_06
Patent number
US08471005B2

Reaction notes

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