1-[(3-Methoxy-4-nitrophenyl)methyl]-2-methyl-1H-imidazole → 2-Methoxy-4-[(2-methyl-1H-imidazol-1-yl)methyl]aniline

HRID 1262070Notes

Reaction equation

HRID 1262070 reaction equation
NC1C=CC(N2CCC[C@H](C(N3CCN(C)CC3)=O)C2)=CC=1OC.[CH3:25][O:26][C:27]1[CH:28]=[C:29]([CH:37]=[CH:38][C:39]=1[N+:40]([O-])=O)[CH2:30][N:31]1[CH:35]=[CH:34][N:33]=[C:32]1[CH3:36]>>[CH3:25][O:26][C:27]1[CH:28]=[C:29]([CH2:30][N:31]2[CH:35]=[CH:34][N:33]=[C:32]2[CH3:36])[CH:37]=[CH:38][C:39]=1[NH2:40]

Participants

3

Reactant 2

HCID 574161371-[(3-Methoxy-4-nitrophenyl)methyl]-2-methyl-1H-imidazoleHCID 66711468HCID 66711468, compound

Product 1

HCID 574160772-Methoxy-4-[(2-methyl-1H-imidazol-1-yl)methyl]aniline

Procedure

2-Methoxy-4-(2-methyl-imidazol-1-ylmethyl)-phenylamine was prepared in an analogous fashion to [(S)-1-(4-Amino-3-methoxy-phenyl)-piperidin-3-yl]-(4-methyl-piperazin-1-yl)-methanone of Example 460c replacing [(S)-1-(3-Methoxy-4-nitro-phenyl)-piperidin-3-yl]-(4-methyl-piperazin-1-yl)-methanone with 1-(3-Methoxy-4-nitro-benzyl)-2-methyl-1H-imidazole.

Sources & evidence

ORD record
ord-86d46f92badc44559114930efe21e2a2
Source dataset
uspto-grants-2013_06
Patent number
US08471005B2

Reaction notes

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