Hydrochloric Acid → HCID 178488501, compound

HRID 1262122Notes

Reaction equation

HRID 1262122 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[C:7]([O:9][CH3:10])[CH:6]=[CH:5][C:4]=1[C:11]1[N:19]2[C:14]([CH:15]=[N:16][C:17](S(C)=O)=[N:18]2)=[CH:13][CH:12]=1.Cl.[OH-:24].[Na+]>>[CH3:1][O:2][C:3]1[CH:8]=[C:7]([O:9][CH3:10])[CH:6]=[CH:5][C:4]=1[C:11]1[N:19]2[C:14]([CH:15]=[N:16][C:17]([OH:24])=[N:18]2)=[CH:13][CH:12]=1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 66711591HCID 66711591, compound

Product 1

HCID 178488501HCID 178488501, compound

Conditions

Temperature
80 °C

Procedure

7-(2,4-Dimethoxy-phenyl)-2-methanesulfinyl-pyrrolo[2,1-f][1,2,4]triazine (605 mg) was suspended in 5M NaOH (20 ml) and heated to 80° C. for 3 hours. Cooled to room temperature and acidified with concentrated HCl. Extracted with dichloromethane. Dried over magnesium sulfate. Concentrated to afford 7-(2,4-dimethoxy-phenyl)-pyrrolo[2,1-f][1,2,4]triazin-2-ol as a brown solid (245 mg) that was used without further purification.

Workup

  1. temperatureCooled to room temperature
  2. extractionExtracted with dichloromethane
  3. dry with materialDried over magnesium sulfate
  4. concentrationConcentrated

Sources & evidence

ORD record
ord-fb761b3a6a88416aa0704d2ae2286405
Source dataset
uspto-grants-2013_06
Patent number
US08471005B2

Reaction notes

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