Trifluoromethanesulfonate → HCID 66712674, compound

HRID 1262167Notes

Reaction equation

HRID 1262167 reaction equation
[N:1]1([CH2:7][CH2:8][O:9][C:10]2[CH:11]=[C:12]([NH2:16])[CH:13]=[CH:14][CH:15]=2)[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.[C:17]([NH:21][S:22]([C:25]1[CH:30]=[CH:29][CH:28]=[C:27]([C:31]2[N:39]3[C:34]([CH:35]=[N:36][C:37](S(C)=O)=[N:38]3)=[CH:33][CH:32]=2)[CH:26]=1)(=[O:24])=[O:23])([CH3:20])([CH3:19])[CH3:18].[O-]S(C(F)(F)F)(=O)=O>>[C:17]([NH:21][S:22]([C:25]1[CH:30]=[CH:29][CH:28]=[C:27]([C:31]2[N:39]3[C:34]([CH:35]=[N:36][C:37]([NH:16][C:12]4[CH:13]=[CH:14][CH:15]=[C:10]([O:9][CH2:8][CH2:7][N:1]5[CH2:6][CH2:5][O:4][CH2:3][CH2:2]5)[CH:11]=4)=[N:38]3)=[CH:33][CH:32]=2)[CH:26]=1)(=[O:23])=[O:24])([CH3:20])([CH3:18])[CH3:19]

Participants

4

Reactant 3

HCID 2758875TrifluoromethanesulfonateHCID 64866163-(2-Morpholin-4-ylethoxy)anilineHCID 66711063N-tert-Butyl-3-(2-methanesulfinyl-pyrrolo[2,1-f][1,2,4]triazin-7-yl)-benzenesulfonamide

Product 1

HCID 66712674HCID 66712674, compound

Procedure

Prepared by following a procedure analagous to Example 251c by using 3-(2-Morpholin-4-yl-ethoxy)-phenylamine and N-tert-Butyl-3-(2-methanesulfinyl-pyrrolo[2,1-f][1,2,4]triazin-7-yl)-benzenesulfonamide as a triflate salt. 1H-NMR (DMSO) δ 9.9 (br s, 1H), 9.6 (s, 1H), 9.15 (s, 1H), 8.5 (s, 1H), 8.4 (d, J=8.0 Hz, 1H), 7.9 (d, J=8.0 Hz, 1H), 7.75 (m, 1H), 7.6 (s, 1H), 7.55 (d, J=8.3 Hz, 1H), 7.3 (m, 2H), 7.2 (d, J=4.7 Hz, 1H), 7 (d, J=4.7 Hz, 1H), 6.7 (d, J=10.4 Hz, 1H), 4.3-3.3 (m, 12H), 1.1 (s, 9H); LC/MS (ESI+): 551 (M+H).

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-5cbfdb9e380846ffb84e18ca8ecc8b29
Source dataset
uspto-grants-2013_06
Patent number
US08471005B2

Reaction notes

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